Fourth Stage💊

Clinical toxicology a5

Q1 / explain ph alteration methods

Q2/ the toxic pathway of APAP ————— account ———— in normal condition , produce ———- toxic intermediate

Clinical toxology B5
Lab1+2
Q1// what is the mechanism of NAC?
Q2/ full the blanks
1-AC may be effective for more than .........for drugs thatdelay gastric emptying.
2- Liver dysfunction determine by........... test
3- Remack mattew can Obtain a serum acetaminophen level ....... hours after ingestion.

Clinical toxicology B1
Lab1+2

Q1/ explain the contraindications in gastric lavage briefly

Q2/ فراغات

1- ____ ia a genetic disorder that Reduces Hepatic Conjugation Capacity and increases the risk of hepatotoxicity

2- chronic alcohol consumption results in __ and ___

Clinical toxicology B6
Lab 1 & lab 2
1. IPECAC SYRUP INDUCE VOMITING LATE AFTER ____ MIN
2. Gastric lavage In adults _ aliquots and in children __ ml
3.Factores that increase Hepatic Glutathione (GSH) Depletion_ and ____
4. Mention four laboratory tests assess in paracetamol toxicity
5.paracetamol doesn’t cross placenta and it’s safe to pregnant (T/F)

كوز توكسو كروب B3
Q1/
1- acetaminophen mainly metabolized by the kidneys (T/F)

2- acetaminophen chronic use increase Glutathione store (T/F)

3- gut dialysis is passing of drug from ____ to the intestines.

4- ipecac syrup induce vomiting by direct irritation of ______.


Q2/ what is toxidrome? Give two examples?

كوز توكسو A6
1-activated charcol use for all type of toxicity (T/F)
2-urin acidification are recommended for toxicity of weak base (T/F)
3- Dialysis base on principle of__
4-what are technique used for patients stabilization?
5-what matthew nomogram used for ?

2_clinical stabilization involve ............ ans/ ABC(airways,breathing,circulation) 3_recomended dose of ipecac for adults is ...... ans/ 30ml 4_ antidote of acetamnophen is........... ans/N_acetyl cysteine 5_hyperkalemia mean.........and caused…

2_clinical stabilization involve ............

ans/ ABC(airways,breathing,circulation)


3_recomended dose of ipecac for adults is ......

ans/ 30ml

4_ antidote of acetamnophen is...........

ans/N_acetyl cysteine


5_hyperkalemia mean.........and caused by ........and.........

ans/increase K(potassium)cons ,decrease renal excretion ,increase K intake



سموم
B2
1_ Dialysis complete replace antidote or specific treatment (T/F)
2_hypokalemia cause by metabolic acidosis(T/F)
Ipeaea use as first line in poison patient.why?
شخص عمرة 36ماخذ جرعة عالية من أدوية اكتئاب ف صار عنده prolonged QRS
1_wich class of drug cause this effect
2_electrophysiological mechanism cause change in ECG


A2 / Lab . clinical toxo

1 - gastric lavage contraindicated if the patient consicous (T/F) T

2- why treat the patient have priority before treat the poison?

3 -In Sinus bradycardia/AV block,β-blockers , Calcium-channel blockers induce automaticity or AV-node conduction.T or F

4- what is the effect of insulin therapy on serum electrolyte and why?

Hypokalemia due to shift potassium into cells

النقطة الخامسة بيها مثل الكيس اكو واحد مسويلة urine imuunoassay وطالعة النتيجة positive وانوب مسويلة chromatoghraphy وطالعة negative . ليش اكو فرق بالنتائج

الجواب حسب كلامة انو ال urine immunoassay ينطي false positive results

Toxo

الكوز الاول


كوز التوكسوA6
عباره عن كيس لشخص متناول metforme وmethanol
وكاتبه الاعراض
تحليل الالكترولايت بشكل جدول وبنهايه الجدول على اساس النسبه تكتب بلحقل شنو الحاله
واكو بعده ٤ اساله عن الكيس
١_شنو تشخيص الحاله
٢_ نطلع AG
والسبب في النسبه لي تطلعه
٣_شنو اهم اختبار نسوي
٤_ شنو راح تسوي حتى تحافظ على حياته في المستشفى .


Toxicology
Group B6
Q1- What main Contraindications to orogastric lavage?فقط رؤوس اقلام
1-The patient has lost or will likely lose his or her airway protective reflexes
2-Ingestion of corrosives.
3-Ingestion of a xenobiotic with a high aspiration potential
4-risk of hemorrhage or gastro intestinal perforation
Q2- mention three factors targeting metabolic acidosis ?
1- methanol. 2- ethanol 3- ethylene glycol …..
Q3- blank الجواب بين الاقواس
1- the adv. of spot test is ( rapid &inexpensive)
2- (BUN and creatinine test) used to evaluate renal function
3- ( fomepizol) is antidote of ethylene glycol
4- urin acidification used for ( weak bases) e.g ( amphetamines)



كوز توكسو group B3 :
1- the principle of dialysis is ……….
2- prolonged QRS caused by ……. And ……..
3- supportive care including ……. And …….
4- ………. Is the advanced version of ……… which use …….
5- chromatography main feature is ……….

الاجوبة :
1- diffusion
2- TCA , phenothiazine , CCB
3- Iv fluids , control symptoms , monitoring
4- spectrochemical test , spot test , light absorption
5- detect multible substances in one procedure


توكسو A3
1- Clinical toxicologist normally works in -------, ------- and -------
2- We can use ------- when the patient is unconscious to protect breathing
3- ipecac used for ------ within ------
Q/ Why is hyperglycemia often associated with hyponatremia ?
Q/ Why is Chromatography used in toxicology?



B1 Toxicology Quiz #توكسو

1- AG increase in metabolic acidosis due to what ?

Ans:- MUDPLIES

2- Mention 3 causes of prolonged QRS?

Ans- TCA , CCB , Phenothiazines

3- treat the poison not the patient T/F

Ans- F

4_ Dayalsis is responsible for evaluating renal function T/F

Ans- F

5_ If AG less that 12 it indicates metabolic acidosis T/F

Ans- F



group A5
#توكسو_عملي

1. activated charcoal bind poorly to ? mention two .
answer/ethanol ,electrolytes

2. Hypernatremia can occurs due to hypertonic water loss ? T or F
answer/ F

3. Dialysis of poisoning patient is complete management with no need to antidote ? T or F
answer/F

4. Potassium sparing diuretics and hypoaldosteronism can cause.................. kalemia.
answer / hyper

5 .شخص رياضي ياخذ مكملات الطاقه (amphetamine ) خلال التمرين و ال urine تحول اللون مالته الى brown-dark . وضح شنو سبب تغير اللون
answer/ amphetamine cause rhabdomyolysis which lead to myoglobinuria.
يعني ال myoglobinuria هيه سبب تغير لون ال urine.



A4 clinical toxicology
Lab 1+2
Urine acidification is widely recommend for the elimination of weak basic drugs
T/F
A/ F ( not recommend) بالملزمة
لان بالملزمة كاتب انو استخدامها الحالي غير موصى به
Insulin therapy and B blocker shifts K
_ cells causing __kalemia
A/ inside or into the cells + hypo
In gastric lavage _ of solution of __ in adults
A/ 2L of saline
Mention two toxicological or drug induced hyponatremia with their mechanism
هذا جوابه من جدول الموجود باللاب تختارون ياما فد حالتين او دواء اثنين وتفسيرلكم اله
واجتنا مسألة تطبيق مباشر عن Anion gap
انو بيشنت اجى للطوارئ وهو عنده حالة من التشتت confusion وفمه جاف وما اتذكر بعد شنو وذكرلنة تراكيز صوديوم وكلور و hco3
صوديوم جان ١٦٢
كلور و hco3 جانت تراكيزهم ٩٤ و ٤٠ وكال انو الطبيب وكتها اشتبه انو مريض يمكن عده
Metabolic acidosis
ف انت توافق طبيب الراي وليش ؟
ف بس تطبقون قانون وتطلعون شكد قيمة الاينون كاب
Ag= Na - ( cl + hco3)
= 162 - ( 110 + 24 )
= 162 - 134
= 28
وبما انو القيمة طلعت اكبر من ١٢ ف معناتها فعلا هو ديصير عنده acidosis ف تجاوبوه بانو نعم اوافق طبيب الراي لان الاينون كاب طلع اكبر من ١٢



B5 #توكسو
Toxicology (lab1+2 quiz)

1_ clinical toxicologist are .........who recieve specialized training in .......&.........

ans/physicians_ emergency medicine &poison managment

Quiz clinical chemistry B5
Q1/ full the blanks
1- ............the oxidation of
glucose to gluconic acid and H2O2.
2- In transfusion of glucose solution is ......... due to ........... and ..........
3- the normal range of cereatinine in man serum is ............
Q2/ what is the pathological that causes increase and dcrease the cereatinine ?

B1 صناعية
Dry granulation

Q1/ فراغات
1- the granulation process enlarges particles by____
2- in slugging process,prepare the formula then_____
3- in roller compaction powder between __and gab __ get smaller
4- generate charge of static electric lead to____

Q2/ calculate the lubricant amount if the real no of tab 17
Warfarin 4mg
acacia 0.16g
MG staerate 0.003g
Prepare 21 tablets

- The roller compaction method transports the powder blend to a
pair of counter-rotating rollers.
This can be done using either ————and ————-

-there are two impotant factor of rollar compactor ———- and ———-


-why dry compression not time consuming


Q2/ مساله نطلع real no of tab


A5

كوز صناعية A3
Dry granulation
Q1/why

1-The disintegration time in dry granulation is improved

2-sod. phenobarbital decompose by heat and moisture

3-Improves storage and transport efficiency

4-Weigh all the substances and ½ amount of lubricant

Q2/ calculate the real number of tablet:
50mg, 30mg
sod.sterate 0.008g
Prepare 38 tab

Total wt. of granules berfor granulation 1.880g
المواد اول ٢ نسيت اسمائها بس هذني تراكيزها والثالثة هي ال Lubricants وانتبهوا لتحويل الوحدات كلها mg لازم ، ونفس الخطوات بس تطلعون عدد التابلت

اني خريجة الجامعة فتحت هذا البيج اشتغل بي بوسترات تخرج وطباعة ملابس وبروشات ورد وشهايد تخرج وجرايد وكل تجهيزات التخرج توزيعات وهدايا وارتب بحوث وانفوجرافيك ممكن تنشر حسابي بكروب دفعتكم اذا عدكم اكون ممنونه منك ❤
هذا رابط الانستا🙏
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clinical chemistry B4


Q1 full in the blank
1. in renal disease the urea level will rise up to ___
2. __ an enzyme can convert a colourless chromogen into coloured substance

3. __ drug can rise the serum creatinine
Q2/
What are the pathological reasons that can rise the serum creatinine

Clinical chemistry quiz
Lab 1+ lab2 B6
Q1
1.Urea represents _ of non protein nitrogen of normal blood.

2.Impaired glucose tolerance (IGT) and Impaired fasting glucose (IFG) values are _ and ____

3.creatinine amount in serum is proportional to __

4._____ gives better information than blood
creatinine test

Q2/ what is the principal of enzymatic glucose test

Clinical chemistry / lab 1+2
كروب A6
Q1/ fill the blank
1- serum creatinine level in man________than women due to__________

2-blood urea level in Newborns is___________

3-In sever liver disease blood urea is________

4-Insulinoma lead to __________glucose level

Q2/FBG level is lower in whole blood than in serum?

Clinical chemistry
كروب A1
Q1/ fill the blanks

1- serum ceratinine level in men is ……

2- phenocytochrome can cause ….. BG while hypothyroidism can cause ……..

3- hyperglycaemia can cause cerebral dysfunction by …..

4- sepsis will …… urea level in serum

Q2/ what is faulty execration in blood urea ?

السلام عليكم الي يذكر اسئله التدريب حتى نفيد الدفعة الي ورانا اكتبوا الاسئله تذكروها بالتعليقات .

Clinical quiz A5

1- creatinine clearance in women —————-
2- Impaired glucose tolerance (IGT) and
Impaired fasting glucose (IFG):
These terms refer to a metabolic stage
intermediate between ————-and ————

3- drugs increases urea ————and ————-

Q2/factors cause hypoglycemia

اسئلة كروب a5 عضوية

قطعة خارجية مالانكليزي اسئلة دكتور محمد
وجوها نقاط وانتوا تحطون بصف نقطة صحيحة agree
واذا مو صحيحة تعوفها فارغة

Mcq دكتور حسين.

1- streptose are difficult to isolated because :-
- too unstable

2- Mechanism of streptomycin :-
-bind to 30s

3-Streptomycin is characterised chemically as an
aminoglycoside antibiotic. It consists of three
components linked:-

-glycosidicaly

4- guanidine hybridization :-
-SP2

كوز مختبر التكسو لكروب - B2

True or False
1. Cyanosis is often evident when the methemoglobin concentration exceeds 70%.
2. Oxidative hemolysis is the formation of free radicals that destruct the hemoglobin of the erythrocyte.
3. Benzene causes Acute myelogenous leukemia (AML).
4. Increase in destruction of thrombocytes causes thrombocytopenia.
5. Fibrinolytic drugs cause fibrin clot formation.

كوز مختبر السريرية
Group A1 ( د.دلين )

Q1/ fill the following blanks

1) ………. Have better oral absorption than ampicillin

2) one of the amikican contra indication is …….

3) dose of ceftriaxone in case of hospital acquired pneumonia is ………

Q2 / in case of pregnancy what is the situation of following drugs ?

- meropenem
- tetracycline

كوز مختبر سريرية :A3

Q1\ Mention 3 indication and dose of ceftriaxone.
Q2\Mention 3 side effect of doxycycline.
Q3 \ Monitoring of Benzyl penicillin (2)
الاجابة عن سؤالين فقط

Clinical quiz A2 Group

Q1) indications and dosage of amoxiclav


Q2) mention monitoring parameters when using benzathine benzylpenicillin
Good luck.

كوز مختبر سريرية B4 :

Q/ mention drug name , group, and two side effects
1_ drug used in caution with cytomegalo_ virus infection ( augmentin)
2_ drug used should be avoid sun light or sun lamp ( doxycycline)
3_ drug used for gram + and gram - and anaerobic, aerobic ( ما متأكدة اما ceftriaxone or meropenem )

اسألة كروب B6
اسألة دكتور محمد سيناريوا و هو الجواب بالنص بس تكتب agree على النقاط الصح

اسألة دكتور حسين mcq بس ماتذكر كل الخيارات بس الاجوبة
1.Which group of antibiotics is streptomycin consider as
A/ aminoglycosides
2. What is the results of alkaline hydrolysis of streptose
A/ conversation to maltose
3.What is the results of alkaline hydrolysis of streptidine
A/ ammonia + streptamine
4. Streptomycin has 3 very basic amine groups in acidic media it gives
A/ poly-cationic ion with positive charge

السلام عليكم ورحمة الله وبركاته
كوز مختبر السريرية كروب B3

فراغات
1- aminoglycoside not used in pregnancy due to _______

2- cephalexin dose in recurrent uti is _____

3- co-amoxiclav caution is ______ and _______

4- benzathine penicillin G contraindication ______

مرحبا
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كوز التوكسو كروب B6:
1- ………. Is seen when methemoglobin is 5-10%
2- bleeding caused by …… drugs
3- …….. is an syndrome of bone marrow not producing enough blood cells
4- thrombocytopenia occurs when increasing…….. or decreasing……….
Q2/ how to treat methemoglobinemia?